옻나무 열수추출물에 의한 운동수행능력향상에 미치는 효과 및 기전 연구 (Hotwater Extract of Rhus Verniciflua Stokes Improves Exercise Performance in Mice)

서지정보

· 발행기관 : 대한약학회
· 수록지 정보 : 약 학 회 지 / 58권 / 3호 / 181 ~ 189페이지
· 저자명 : 김민지, 나천수, 유영춘, 홍철이

초록

The aim of this was to evaluate the effects of Rhus Verniciflua Stoke (RVS) extract powder on the endurancecapacity for the forced swimming mice. Thirty mice were divided into 3 groups including negative control, 250 (RVS-250)and 500 (RVS-500) mg/kg RVS extract powder groups for 4-times swimming exercises. The swimming times to exhaustionin RVS-250 and RVS-500 mice were prolonged 1.6- and 2.0-fold at 4 weeks compared with negative control mice, respectively. Blood biochemical parameters for AST, ALT, T-CHO and TG were not significantly different between RVS fed or negativecontrol mice. However, blood concentration of creatinine was significantly increased in RVS-250 mice, but not in RVS-500 mice. During the longer swimming exercise in RVS group, blood glucose and lactate levels were significantly decreased,but free fatty acid not changed. And also LDH levels were significantly decreased in RVS groups compared to negative controlmice. Hepatic lipid peroxidation was not affected by RVS, but SOD and catalase activity were significantly increased inRVS groups. Interestingly, the levels of testosterone and free testosterone were significantly increased in RVS groups beforeswimming exercise, but they were not significantly changed among groups after swimming exercise. The present resultssuggest that RVS extract powders may enhance swimming exercise performance by recovering the exercise-fatigue viareduction of blood LDH activity and by burning blood glucose as an energy source. These results imply that RVS-producedtestosterone may act as an energy buster to enhance physical activity.

영어초록

The aim of this was to evaluate the effects of Rhus Verniciflua Stoke (RVS) extract powder on the endurancecapacity for the forced swimming mice. Thirty mice were divided into 3 groups including negative control, 250 (RVS-250)and 500 (RVS-500) mg/kg RVS extract powder groups for 4-times swimming exercises. The swimming times to exhaustionin RVS-250 and RVS-500 mice were prolonged 1.6- and 2.0-fold at 4 weeks compared with negative control mice, respectively. Blood biochemical parameters for AST, ALT, T-CHO and TG were not significantly different between RVS fed or negativecontrol mice. However, blood concentration of creatinine was significantly increased in RVS-250 mice, but not in RVS-500 mice. During the longer swimming exercise in RVS group, blood glucose and lactate levels were significantly decreased,but free fatty acid not changed. And also LDH levels were significantly decreased in RVS groups compared to negative controlmice. Hepatic lipid peroxidation was not affected by RVS, but SOD and catalase activity were significantly increased inRVS groups. Interestingly, the levels of testosterone and free testosterone were significantly increased in RVS groups beforeswimming exercise, but they were not significantly changed among groups after swimming exercise. The present resultssuggest that RVS extract powders may enhance swimming exercise performance by recovering the exercise-fatigue viareduction of blood LDH activity and by burning blood glucose as an energy source. These results imply that RVS-producedtestosterone may act as an energy buster to enhance physical activity.

참고자료

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