혈관염을 동반한 DRESS 증후군 1예 (A Case of DRESS Syndrome Accompanied by Leukocytoclastic Vasculitis)

서지정보

· 발행기관 : 대한천식알레르기학회
· 수록지 정보 : 천식 및 알레르기 / 30권 / 4호 / 320 ~ 324페이지
· 저자명 : 위정욱, 진남철, 한의령, 윤병조, 박상훈, 고영일

초록

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a drug hypersensitivity syndrome characterized by fever, skin rash, blood eosinophilia and multiple organ involvements including liver and kidney developed following drug administration. Vasculitis could be infrequent one of manifestations of DRESS syndrome.
Mortality rate of DRESS syndrome is at least 10%. Here,we reported a case of DRESS syndrome with vasculitis. A 67-year-old man with essential hypertension presented with fever and maculopapular rash after being given allopurinol over 2 weeks for gout. He had severe oral mucositis. He had peripheral blood eosinophilia and abnormal hepatic and renal functions. A skin biopsy showed leukocytoclastic vasculitis. Gastroduodenoscopy showed spontaneous mucosal oozing in mid-to-lower esophagus. He was diagnosed as having DRESS syndrome with vasulitis. Allopurinol was stopped and systemic corticosteroid was administrated. His clinical manifestations improved gradually. However, he died of sudden onset of massive intracranial hemorrhage.
The case suggests that DRESS syndrome could sometimes present manifestations of vasculitis, which might be fatal.

영어초록

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a drug hypersensitivity syndrome characterized by fever, skin rash, blood eosinophilia and multiple organ involvements including liver and kidney developed following drug administration. Vasculitis could be infrequent one of manifestations of DRESS syndrome.
Mortality rate of DRESS syndrome is at least 10%. Here,we reported a case of DRESS syndrome with vasculitis. A 67-year-old man with essential hypertension presented with fever and maculopapular rash after being given allopurinol over 2 weeks for gout. He had severe oral mucositis. He had peripheral blood eosinophilia and abnormal hepatic and renal functions. A skin biopsy showed leukocytoclastic vasculitis. Gastroduodenoscopy showed spontaneous mucosal oozing in mid-to-lower esophagus. He was diagnosed as having DRESS syndrome with vasulitis. Allopurinol was stopped and systemic corticosteroid was administrated. His clinical manifestations improved gradually. However, he died of sudden onset of massive intracranial hemorrhage.
The case suggests that DRESS syndrome could sometimes present manifestations of vasculitis, which might be fatal.

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