NC/Nga 마우스에서의 아토피피부염 유사 병변에 대한 Light Emitting Diode의 치료 효과 (Therapeutic Effects of Light Emitting Diode on Atopic Dermatitis-Like Lesions in NC/Nga Mice)

서지정보

· 발행기관 : 대한천식알레르기학회
· 수록지 정보 : 천식 및 알레르기 / 31권 / 3호 / 207 ~ 214페이지
· 저자명 : 임윤영, 장우선, 김형미, 김인수, 이진웅, 김명남, 김범준

초록

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It is caused by immunological abnormalities,abnormalities of the skin barrier, and environmental/genetic factors. We did a preclinical trial to identify the effects of the 633-nm light- emitting diode (LED) and 830-nm LED for AD-like lesions in NC/Nga mice.
Methods: AD-like skin lesions were induced by topical application of Dermatophagoides farinae extract on the skin of 5-week-old NC/Nga mice for 2 weeks, and then was treated with 630-nm or 830-nm LED for 1 week. We identified any therapeutic effects on AD using modified SCORAD index, skin biopsy, and measurements of both transepidermal water loss (TEWL) and proinflammatory cytokines.
Results: Both of 630-nm and 830-nm LED treatment groups showed significantly reduced SCORAD indices and TEWLs at the end of treatment, compared to the non-treatment group. In addition, the levels of proinflammatory cytokine levels in both of the LED treatment groups were significantly decreased compared to those in the non-treatment group.
Conclusion: These results show that 633-nm and 830-nm LED treatments can improve -like lesions in NC/Nga mice.

영어초록

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It is caused by immunological abnormalities,abnormalities of the skin barrier, and environmental/genetic factors. We did a preclinical trial to identify the effects of the 633-nm light- emitting diode (LED) and 830-nm LED for AD-like lesions in NC/Nga mice.
Methods: AD-like skin lesions were induced by topical application of Dermatophagoides farinae extract on the skin of 5-week-old NC/Nga mice for 2 weeks, and then was treated with 630-nm or 830-nm LED for 1 week. We identified any therapeutic effects on AD using modified SCORAD index, skin biopsy, and measurements of both transepidermal water loss (TEWL) and proinflammatory cytokines.
Results: Both of 630-nm and 830-nm LED treatment groups showed significantly reduced SCORAD indices and TEWLs at the end of treatment, compared to the non-treatment group. In addition, the levels of proinflammatory cytokine levels in both of the LED treatment groups were significantly decreased compared to those in the non-treatment group.
Conclusion: These results show that 633-nm and 830-nm LED treatments can improve -like lesions in NC/Nga mice.

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