항생제 치료로 유발된 혈액응고 제V인자에 대한 후천적 억제인자 (Antibiotic-Induced Acquired Factor V Inhibitor)

서지정보

· 발행기관 : 대한내과학회
· 수록지 정보 : 대한내과학회지 / 87권 / 1호 / 105 ~ 109페이지
· 저자명 : 임두호, 김태오, 정유문, 김원장, 박승정, 이제환, 장성수

초록

Acquired factor V inhibitor is a rare condition with a variety of clinical manifestations that range from no bleeding symptoms tolife-threatening hemorrhage or thromboembolic events. Treatment is determined by the clinical course and focuses on controllingthe hemorrhagic event and decreasing the antibody titer if bleeding symptoms are present. We report herein a case involving a70-year-old man who developed acquired factor V inhibitor after antibiotic administration (11-day course of ceftriaxone andsuccessive 5-day course of piperacillin-tazobactam) for pneumonia. His condition was characterized by elevated prothrombin andactivated partial thromboplastin times without bleeding events. Coagulation factor assays revealed undetectable factor V activityand a factor V inhibitor level of 3.29 Bethesda units. After cessation of the antibiotics, both the prothrombin and activated partialthromboplastin times gradually normalized.

영어초록

Acquired factor V inhibitor is a rare condition with a variety of clinical manifestations that range from no bleeding symptoms tolife-threatening hemorrhage or thromboembolic events. Treatment is determined by the clinical course and focuses on controllingthe hemorrhagic event and decreasing the antibody titer if bleeding symptoms are present. We report herein a case involving a70-year-old man who developed acquired factor V inhibitor after antibiotic administration (11-day course of ceftriaxone andsuccessive 5-day course of piperacillin-tazobactam) for pneumonia. His condition was characterized by elevated prothrombin andactivated partial thromboplastin times without bleeding events. Coagulation factor assays revealed undetectable factor V activityand a factor V inhibitor level of 3.29 Bethesda units. After cessation of the antibiotics, both the prothrombin and activated partialthromboplastin times gradually normalized.

참고자료

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