기저세포암과 편평세포암에서 E-cadherin 및Vimentin 발현에 의한 상피-간엽 전환 (The Epithelial-Mesenchymal Transition and E-cadherin and Vimentin Expression in Basal Cell Carcinoma and Squamous Cell Carcinoma)

서지정보

· 발행기관 : 대한피부과학회
· 수록지 정보 : 대한피부과학회지 / 53권 / 2호 / 96 ~ 105페이지
· 저자명 : 김영욱, 김계정, 허은필

초록

Background: The epithelial-mesenchymal transition (EMT) in epithelial tumor cells plays a key role in tumorinvasion and metastasis. The reduction or loss of E-cadherin and the acquisition of vimentin are two critical stepsin the EMT. However, the roles of EMT-related proteins in basal cell carcinomas (BCC) and squamous cellcarcinomas (SCC) have not been fully elucidated.
Objective: The purpose of this study was to investigate the immunohistochemical expressions of E-cadherin andvimentin in BCC and SCC, and to demonstrate the EMT and its role in tumor invasion.
Methods: Paraffin-embedded tissues from 30 BCC and 20 SCC cases were incubated with primary antibodies toE-cadherin and vimentin. The co-expression of the biomarkers and the biomarkers’ correlations with thehistopathological grades were analyzed.
Results: E-cadherin expression reduced by 90.0% and 95.0% in BCC and SCC, respectively, and the expression ofvimentin increased by 10.0% and 55.0% in BCC and SCC, respectively. The expression of vimentin wassignificantly different in BCC and SCC (p＜0.05). There were no correlations between the expression of E-cadherinand the expression of vimentin in BCC (p＞0.05), or between the expression of E-cadherin and the expression ofvimentin in SCC (p＞0.05).
Conclusion: These results suggest that the EMT affects the pathophysiology of both BCC and SCC. The greateraberrance in the expression of vimentin in SCC compared with that in BCC might be one factor that underlies thegreater aggression of SCC clinically.

영어초록

Background: The epithelial-mesenchymal transition (EMT) in epithelial tumor cells plays a key role in tumorinvasion and metastasis. The reduction or loss of E-cadherin and the acquisition of vimentin are two critical stepsin the EMT. However, the roles of EMT-related proteins in basal cell carcinomas (BCC) and squamous cellcarcinomas (SCC) have not been fully elucidated.
Objective: The purpose of this study was to investigate the immunohistochemical expressions of E-cadherin andvimentin in BCC and SCC, and to demonstrate the EMT and its role in tumor invasion.
Methods: Paraffin-embedded tissues from 30 BCC and 20 SCC cases were incubated with primary antibodies toE-cadherin and vimentin. The co-expression of the biomarkers and the biomarkers’ correlations with thehistopathological grades were analyzed.
Results: E-cadherin expression reduced by 90.0% and 95.0% in BCC and SCC, respectively, and the expression ofvimentin increased by 10.0% and 55.0% in BCC and SCC, respectively. The expression of vimentin wassignificantly different in BCC and SCC (p＜0.05). There were no correlations between the expression of E-cadherinand the expression of vimentin in BCC (p＞0.05), or between the expression of E-cadherin and the expression ofvimentin in SCC (p＞0.05).
Conclusion: These results suggest that the EMT affects the pathophysiology of both BCC and SCC. The greateraberrance in the expression of vimentin in SCC compared with that in BCC might be one factor that underlies thegreater aggression of SCC clinically.

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