관상피내암, 관상피내암을 포함한 침윤성 유관암 및 점액성암에서 HER-2/neu와 Paxillin의 발현 양상 (Expression of HER-2/neu and paxillin in ductal carcinoma in situ, invasive ductal carcinoma with ductal carcinoma in situ and mucinous carcinoma)

서지정보

· 발행기관 : 한국유방암학회
· 수록지 정보 : Journal of Breast Cancer / 11권 / 3호 / 109 ~ 115페이지
· 저자명 : 한선욱, 최윤영, 우희두, 손두민, 배상호, 강길호, 김성용, 백무준, 임철완, 이문수, 김창호, 이민혁, 노진혁, 조현득, 오미혜, 김의한, 조무식

초록

Purpose : We purpose to determine the correlation of HER-2/neu and paxillin expression in ductal carcinoma in situ(DCIS), invasive ductal carcinoma with ductal carcinoma in situ(IDC with DCIS) and mucinous carcinoma.
Method : To evaluate the expression of HER-2/neu and paxillin, the immunohistochemical staining was performed for 13 cases of DCIS, 13 cases of IDC with DCIS and 6 cases of mucinous carcinoma.
Results : The DCIS and IDC were associated with infiltration of the inflammatory cells, especially in the comedo type and solid type of tumor. In cases with infiltration of the inflammatory cells, HER-2/neu and paxillin were strongly expressed. When comparing the expression level of HER-2/neu from adjacent normal tissue between DCIS and IDC with DCIS, expression of HER-2/neu was similar to that of normal tissue adjacent to DCIS.
However, in the adjoining normal ductal epithelial cells, paxillin was highly expressed in cells of all of the tumor types, and especially for IDC with DCIS. HER-2/neu and paxillin were not expressed in mucinous carcinoma cells in all cases.
Conclusion : HER-2/neu in the DCIS and IDC with infiltration of inflammatory cells shows higher expression than non-inflammatory DCIS and IDC. If normal duct epithelial cells show a high level of HER-2/neu expression, the epithelial cells have a high probability of transformation into anaplastic cells. However, paxillin appears to have no value as a prognostic factor. The difference of expression of HER-2/neu between IDC with DCIS and DCIS suggests a different origin of tumor cells. The growth pattern of mucinous carcinoma cell is different from the that of DCIS or IDC cell, which grow slowly.

영어초록

Purpose : We purpose to determine the correlation of HER-2/neu and paxillin expression in ductal carcinoma in situ(DCIS), invasive ductal carcinoma with ductal carcinoma in situ(IDC with DCIS) and mucinous carcinoma.
Method : To evaluate the expression of HER-2/neu and paxillin, the immunohistochemical staining was performed for 13 cases of DCIS, 13 cases of IDC with DCIS and 6 cases of mucinous carcinoma.
Results : The DCIS and IDC were associated with infiltration of the inflammatory cells, especially in the comedo type and solid type of tumor. In cases with infiltration of the inflammatory cells, HER-2/neu and paxillin were strongly expressed. When comparing the expression level of HER-2/neu from adjacent normal tissue between DCIS and IDC with DCIS, expression of HER-2/neu was similar to that of normal tissue adjacent to DCIS.
However, in the adjoining normal ductal epithelial cells, paxillin was highly expressed in cells of all of the tumor types, and especially for IDC with DCIS. HER-2/neu and paxillin were not expressed in mucinous carcinoma cells in all cases.
Conclusion : HER-2/neu in the DCIS and IDC with infiltration of inflammatory cells shows higher expression than non-inflammatory DCIS and IDC. If normal duct epithelial cells show a high level of HER-2/neu expression, the epithelial cells have a high probability of transformation into anaplastic cells. However, paxillin appears to have no value as a prognostic factor. The difference of expression of HER-2/neu between IDC with DCIS and DCIS suggests a different origin of tumor cells. The growth pattern of mucinous carcinoma cell is different from the that of DCIS or IDC cell, which grow slowly.

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