골수이식환자의 부비동 방사선 양성소견의 의의 (The Significance of Radiologic Positive Finding of Paranasal Sinus in Bone Marrow Transplant Patients)

서지정보

· 발행기관 : 대한비과학회
· 수록지 정보 : Journal of Rhinology / 15권 / 2호 / 120 ~ 123페이지
· 저자명 : 윤성재, 신창민, 이혜령, 허준영, 김정수, 김태훈, 조인지

초록

Background：Bone marrow transplantation (BMT) is a beneficial and curative technique used in different hematologic
conditions or malignant neoplastic diseases. However, bone marrow transplant patients are at a higher risk of developing infections
and complications due to previous chemotherapy, radiotherapy, immunosuppression, antibiotics therapy, multiple viral
infections, and GVHD (graft-versus-host disease). Objectives：The purpose of this study is to determine the prevalence and
clinical data of rhinosinusitis among patients with BMT. We also investigated whether pre-BMT positive radiologic finding
could predispose patients to the development of post-BMT rhinosinusitis or not. Materials and Methods：We reviewed the
records of 203 patients who had received BMT in Kyungpook National University’s hospital from September 1998 to August
2006. Result：Sixteen patients (7.8%) had radiologic positive finding before BMT. Fifteen patients had no sinonasal symptoms
and did not get any treatment. Only one patient had rhinosinusitis so that BMT was delayed and treated with antibiotics.
Among these patients, one patient got newly developed rhinosinusitis after BMT. After BMT, sinusitis developed in ten patients
(4.9%), including one patient who had invasive fungal sinusitis. Our study revealed a higher incidence of rhinosinusitis among
allogenic BMT patients than among autologous BMT patients. The most common symptoms and signs were fever. Only one
patient complained of typical sinonasal symptoms. Conclusion：Even though the prevalence of rhinosinusitis is low (4.9%)
among post-BMT patients, maintenance of a high index of suspicion among these patients is necessary because sinonasal symptoms
and signs are generally minimized after BMT. The study concluded that pre-BMT positive radiologic findings without
sinonasal symptoms is unlikely to develop post-BMT rhinosinusitis.

영어초록

Background：Bone marrow transplantation (BMT) is a beneficial and curative technique used in different hematologic
conditions or malignant neoplastic diseases. However, bone marrow transplant patients are at a higher risk of developing infections
and complications due to previous chemotherapy, radiotherapy, immunosuppression, antibiotics therapy, multiple viral
infections, and GVHD (graft-versus-host disease). Objectives：The purpose of this study is to determine the prevalence and
clinical data of rhinosinusitis among patients with BMT. We also investigated whether pre-BMT positive radiologic finding
could predispose patients to the development of post-BMT rhinosinusitis or not. Materials and Methods：We reviewed the
records of 203 patients who had received BMT in Kyungpook National University’s hospital from September 1998 to August
2006. Result：Sixteen patients (7.8%) had radiologic positive finding before BMT. Fifteen patients had no sinonasal symptoms
and did not get any treatment. Only one patient had rhinosinusitis so that BMT was delayed and treated with antibiotics.
Among these patients, one patient got newly developed rhinosinusitis after BMT. After BMT, sinusitis developed in ten patients
(4.9%), including one patient who had invasive fungal sinusitis. Our study revealed a higher incidence of rhinosinusitis among
allogenic BMT patients than among autologous BMT patients. The most common symptoms and signs were fever. Only one
patient complained of typical sinonasal symptoms. Conclusion：Even though the prevalence of rhinosinusitis is low (4.9%)
among post-BMT patients, maintenance of a high index of suspicion among these patients is necessary because sinonasal symptoms
and signs are generally minimized after BMT. The study concluded that pre-BMT positive radiologic findings without
sinonasal symptoms is unlikely to develop post-BMT rhinosinusitis.

참고자료

· 없음