아젤라인산을 함유한 여드름용 화장품 제형의 안정성 (Stability of Acne Cosmetics Containing Azelaic Acid)

서지정보

· 발행기관 : 대한미용학회
· 수록지 정보 : 대한미용학회지 / 6권 / 2호 / 113 ~ 119페이지
· 저자명 : 장기호, 하병조

초록

High concentration of azelaic acid which is non-soluble to water, oil and ethanol was studied. The cosolvents were used to raise aqueous solution concentration and solubilizing agents were used to prevent from recrystallizing. And the neutralizers were used to raise stability of aqueous solution neutralized as rate of equivalent. Polysorbate 80, polysorbate 60, and lysolecithin were used for solubilizing agents and triethanolamine, arginine, and sodium hydroxide were used for neutralizer. The compositions of azelaic acid were 16% for azelaic acid, 12% for lysolecithin, 37% for propylene glycol, 35% for water, respectively. The solubility of azelaic acid to water was increased to 16% from 0.2%. And its solubility was increased 11% from 0.2% when propylene glycol as cosolvent was used and surfactant was not. Also, solubility for azelaic acid salts were increased in 35% and 30%, respectively when triethanolamine and arginine as rate of equivalent of azelaic acid were used to control pH. The solubilities of surfactant, cosolvent and neutralizer which affected product stability were as follows; in case of the surfactants 25% for lysolecithin, 24% for polysorbate 80 and 23% for polysorbate 60. In case of cosolvents, 12% for propylene glycol, 14% for polyethylene glycol, 2% for glycerine and 0.2% for sorbitol. In case of the neutralizers, the solubilities of azelaic acid increased with sodium hydroxide, arginine and triethanolamine in sequence.

영어초록

High concentration of azelaic acid which is non-soluble to water, oil and ethanol was studied. The cosolvents were used to raise aqueous solution concentration and solubilizing agents were used to prevent from recrystallizing. And the neutralizers were used to raise stability of aqueous solution neutralized as rate of equivalent. Polysorbate 80, polysorbate 60, and lysolecithin were used for solubilizing agents and triethanolamine, arginine, and sodium hydroxide were used for neutralizer. The compositions of azelaic acid were 16% for azelaic acid, 12% for lysolecithin, 37% for propylene glycol, 35% for water, respectively. The solubility of azelaic acid to water was increased to 16% from 0.2%. And its solubility was increased 11% from 0.2% when propylene glycol as cosolvent was used and surfactant was not. Also, solubility for azelaic acid salts were increased in 35% and 30%, respectively when triethanolamine and arginine as rate of equivalent of azelaic acid were used to control pH. The solubilities of surfactant, cosolvent and neutralizer which affected product stability were as follows; in case of the surfactants 25% for lysolecithin, 24% for polysorbate 80 and 23% for polysorbate 60. In case of cosolvents, 12% for propylene glycol, 14% for polyethylene glycol, 2% for glycerine and 0.2% for sorbitol. In case of the neutralizers, the solubilities of azelaic acid increased with sodium hydroxide, arginine and triethanolamine in sequence.

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