알츠하이머병, 기억성 경도인지장애, 피질하 유형의 혈관성치매와 혈관성 경도인지장애에서 육체기능 저하가 도구일상생활능력에 미치는 영향 (Effect of Physical Disability on Instrumental Activities of Daily Living in Alzheimer’s Disease, Amnestic Mild Cognitive Impairment (MCI), and Vascular Dementia and Vascular MCI of Subcortical Type)

서지정보

· 발행기관 : 대한신경과학회
· 수록지 정보 : 대한신경과학회지 / 27권 / 4호 / 355 ~ 361페이지
· 저자명 : 김성래, 황혜란, 최윤재, 송창석, 지기환, 최성혜, 김소현, 김일곤

초록

Background: Physical disability may result in some impairment of the score for Instrumental Activities of Daily Living
(IADL). The aim of this study was to evaluate the effect of physical disability on IADL in patients with Alzheimer’s
disease (AD), amnestic mild cognitive impairment (aMCI), subcortical vascular dementia (SVD), and vascular mild
cognitive impairment of the subcortical type (svMCI).
Methods: Fifty-six patients with AD, 30 with SVD, 27 with aMCI, and 21 with svMCI were recruited consecutively from
a memory clinic. Informants for the subjects completed a Korean version of the IADL (K-IADL). In addition, the
informants were asked to choose the cause of each dependent activity of K-IADL from the following: cognitive
impairment, physical disability, or both. The cause of the physical disability was defined as being focal neurologic
symptoms, other physical disease, or both.
Results: Compared to AD patients, SVD patients had higher K-IADL scores [2.02±0.80 (mean±SD) vs. 1.45±0.90, p<0.01]
and focal neurologic signs (FNS; 8.0±5.8 vs. 0.0±0.0, p<0.001), and lower Barthel Index scores (14.7±5.1 vs. 19.6±1.2,
p<0.001). Patients with svMCI had higher FNS (3.8±4.5 vs. 0.0±0.0, p<0.001) compared to those with aMCI. The most
common cause of dependency of activities in K-IADL was cognitive impairment in AD, aMCI, and svMCI patients, and
the combined effect of cognitive impairment and physical disability in those with SVD. The cause of physical disability
was FNS in 96% of SVD patients and in all patients with svMCI.
Conclusions: The effects of FNS as well as cognitive impairment should be considered when measuring the IADL of the
patients with SVD or svMCI.

영어초록

Background: Physical disability may result in some impairment of the score for Instrumental Activities of Daily Living
(IADL). The aim of this study was to evaluate the effect of physical disability on IADL in patients with Alzheimer’s
disease (AD), amnestic mild cognitive impairment (aMCI), subcortical vascular dementia (SVD), and vascular mild
cognitive impairment of the subcortical type (svMCI).
Methods: Fifty-six patients with AD, 30 with SVD, 27 with aMCI, and 21 with svMCI were recruited consecutively from
a memory clinic. Informants for the subjects completed a Korean version of the IADL (K-IADL). In addition, the
informants were asked to choose the cause of each dependent activity of K-IADL from the following: cognitive
impairment, physical disability, or both. The cause of the physical disability was defined as being focal neurologic
symptoms, other physical disease, or both.
Results: Compared to AD patients, SVD patients had higher K-IADL scores [2.02±0.80 (mean±SD) vs. 1.45±0.90, p<0.01]
and focal neurologic signs (FNS; 8.0±5.8 vs. 0.0±0.0, p<0.001), and lower Barthel Index scores (14.7±5.1 vs. 19.6±1.2,
p<0.001). Patients with svMCI had higher FNS (3.8±4.5 vs. 0.0±0.0, p<0.001) compared to those with aMCI. The most
common cause of dependency of activities in K-IADL was cognitive impairment in AD, aMCI, and svMCI patients, and
the combined effect of cognitive impairment and physical disability in those with SVD. The cause of physical disability
was FNS in 96% of SVD patients and in all patients with svMCI.
Conclusions: The effects of FNS as well as cognitive impairment should be considered when measuring the IADL of the
patients with SVD or svMCI.

참고자료

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