CCl4로 유도된 흰쥐의 간기능 손상에 대한 좌우 陽陵泉 전침 효과 비교 연구 (Comparative study on the effects of 2 Hz electroacupuncture stimulation at left and right GB34's in CCl4-intoxicated rats)

서지정보

· 발행기관 : 경락경혈학회
· 수록지 정보 : Korean Journal of Acupuncture / 25권 / 4호 / 119 ~ 132페이지
· 저자명 : 이지영, 양기영, 이병렬, 임윤경

초록

Objectives : To compare the effects of low-frequency electro-acupuncture (EA) stimulation at left and right GB34s on hepatotoxicity in CCl4-intoxicated rats.
Methods : Rats were injected with CCl4 and treated with 2 Hz electro-acupuncture (EA) at left and right GB34s for 15 minutes 3 times per week, for 10 weeks. Holder group, injected with CCl4 and strained in a cylinder for same period as the EA group, was established to compare the hepatotoxicity against the two electroacupuncture groups. To estimate the effects of EA on hepatotoxicity in rats, body weight, liver weight and liver index were measured. Biochemical assays for serum ALT, AST, ALP and total cholesterol ; hematological analysis for RBC, WBC, PLT, hemoglobin, lymphocytes, neutrophils and monocytes ; and histology analysis of liver tissue were also performed.
Results : Lymphocyte level in blood was significantly decreased by CCl4-intoxication, and increased by low-frequency electroacupuncture applied on both left and right GB34s. Low-frequency EA applied on right and left GB34s significantly reduced serum ALT and AST, both of which had been increased by CCl4-intoxication.
Conclusion : Low-frequency electroacupunctures at both left and right GB34s have hepatoprotective effects on CCl4-induced liver damage in rats. However, no significant differences were found between the effects of EAs at left and right GB34s.

영어초록

Objectives : To compare the effects of low-frequency electro-acupuncture (EA) stimulation at left and right GB34s on hepatotoxicity in CCl4-intoxicated rats.
Methods : Rats were injected with CCl4 and treated with 2 Hz electro-acupuncture (EA) at left and right GB34s for 15 minutes 3 times per week, for 10 weeks. Holder group, injected with CCl4 and strained in a cylinder for same period as the EA group, was established to compare the hepatotoxicity against the two electroacupuncture groups. To estimate the effects of EA on hepatotoxicity in rats, body weight, liver weight and liver index were measured. Biochemical assays for serum ALT, AST, ALP and total cholesterol ; hematological analysis for RBC, WBC, PLT, hemoglobin, lymphocytes, neutrophils and monocytes ; and histology analysis of liver tissue were also performed.
Results : Lymphocyte level in blood was significantly decreased by CCl4-intoxication, and increased by low-frequency electroacupuncture applied on both left and right GB34s. Low-frequency EA applied on right and left GB34s significantly reduced serum ALT and AST, both of which had been increased by CCl4-intoxication.
Conclusion : Low-frequency electroacupunctures at both left and right GB34s have hepatoprotective effects on CCl4-induced liver damage in rats. However, no significant differences were found between the effects of EAs at left and right GB34s.

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