전신경련성 간질중첩증 환자 43례에 대한 임상적 연구 (A Clinical Study on 43 Patients with Generalized Convulsive Status Epilepticus)

서지정보

· 발행기관 : 고신대학교(의대) 고신대학교 의과대학 학술지
· 수록지 정보 : 고신대학교 의과대학 학술지 / 14권 / 1호 / 73 ~ 80페이지
· 저자명 : 김광수, 이주호, 유경무

초록

Background : Status epilepticus (SE) is a major neurological and medical emergency requiring prompt treatment to prevent significant brain damage and possible mortality. Despite advances in current treatment technique, SE is still associated with a significant morbidity and mortality.
Methods : Retrospective study from Kosin University Gospel Hospital has been utilized to investigate several clinical factors associated with SE. We stuided the etiology, clinical features, and outcomes of 43 patients over the age of 10 years with generalized convulsive SE.
Results : The majority of patients (69.8%) had no history of previous seizures. CNS infection and alcohol withdrawal were the most prominent causes of SE. The other principle etiologies were idiopathic, head trauma, congenital anomaly, CVA, metabolic disorder, and brain tumor. Among 43 patients, twenty-two patients (51.2%) showed primary generalized tonic-clonic SE and the remainder had secondarily generalized partial SE. Frontal lobe was the most common anatomical site of lesion proven by brain CT or MRI. Thirty-nine patients (90.7%) recovered without neurological sequelae, and 4 patients (9.3%) died.
Conclusion : Generalized convulsive SE associated with CNS infection was the most common, and caused a grave outcome.

영어초록

Background : Status epilepticus (SE) is a major neurological and medical emergency requiring prompt treatment to prevent significant brain damage and possible mortality. Despite advances in current treatment technique, SE is still associated with a significant morbidity and mortality.
Methods : Retrospective study from Kosin University Gospel Hospital has been utilized to investigate several clinical factors associated with SE. We stuided the etiology, clinical features, and outcomes of 43 patients over the age of 10 years with generalized convulsive SE.
Results : The majority of patients (69.8%) had no history of previous seizures. CNS infection and alcohol withdrawal were the most prominent causes of SE. The other principle etiologies were idiopathic, head trauma, congenital anomaly, CVA, metabolic disorder, and brain tumor. Among 43 patients, twenty-two patients (51.2%) showed primary generalized tonic-clonic SE and the remainder had secondarily generalized partial SE. Frontal lobe was the most common anatomical site of lesion proven by brain CT or MRI. Thirty-nine patients (90.7%) recovered without neurological sequelae, and 4 patients (9.3%) died.
Conclusion : Generalized convulsive SE associated with CNS infection was the most common, and caused a grave outcome.

참고자료

· 없음