경구당 부하 후 혈당의 상승이 관상동맥 혈류 예비력에 미치는 영향 (The Effect of Hyperglycemia Induced by Oral Glucose Loading on Coronary Flow Reserve)

서지정보

· 발행기관 : 대한심장학회
· 수록지 정보 : Korean Circulation Journal / 38권 / 4호 / 220 ~ 226페이지
· 저자명 : 송미진, 김남호, 이안생, 최준호, 김용철, 김승환, 박은미, 이상재, 윤경호, 이은미, 유남진, 오석규, 정진원

초록

Background and Objectives: Patients with chronic diabetes mellitus (DM) have an increased risk of cardiac dysfunction
and mortality. There is some evidence that suggests acute hyperglycemia may cause vascular dysfunction.
However, it is unknown whether acute, short-term hyperglycemia affects coronary microcirculation function in
healthy subjects. The present study was undertaken to explore this issue. Subjects and Methods: We evaluated
20 healthy males who had no history of DM or impaired glucose tolerance, ranging in age from 23 to 36 years
(25.9±3.3 years). We checked blood sugar, 12-lead electrocardiography, pulse wave velocity, and coronary flow
reserve using echocardiography during fasting, and 30, 60, 90, and 120 minutes after ingestion of 75 g of glucose
orally. Results: Non-significant prolongation of the QTc dispersion was observed after the 75 g glucose loading.
No significant difference in the pulse wave velocity of the carotid-to-femoral artery, carotid-to-radial artery, or
femoral-to-dorsalis pedis artery was observed after the 75 g glucose loading. There was a significant reduction in the
coronary flow reserve at 60 (4.06±0.75 vs. 3.54±0.82, p=0.021) and 90 minutes (4.06±0.75 vs. 3.59±0.63,
p=0.021) after the 75 g glucose loading compared to that on fasting. Conclusion: The results of this study suggest
that acute exposure to high circulating glucose levels does not affect heterogeneity of the ventricular repolarization
or arterial stiffness, but it does reduce the coronary flow reserve in healthy young men.

영어초록

Background and Objectives: Patients with chronic diabetes mellitus (DM) have an increased risk of cardiac dysfunction
and mortality. There is some evidence that suggests acute hyperglycemia may cause vascular dysfunction.
However, it is unknown whether acute, short-term hyperglycemia affects coronary microcirculation function in
healthy subjects. The present study was undertaken to explore this issue. Subjects and Methods: We evaluated
20 healthy males who had no history of DM or impaired glucose tolerance, ranging in age from 23 to 36 years
(25.9±3.3 years). We checked blood sugar, 12-lead electrocardiography, pulse wave velocity, and coronary flow
reserve using echocardiography during fasting, and 30, 60, 90, and 120 minutes after ingestion of 75 g of glucose
orally. Results: Non-significant prolongation of the QTc dispersion was observed after the 75 g glucose loading.
No significant difference in the pulse wave velocity of the carotid-to-femoral artery, carotid-to-radial artery, or
femoral-to-dorsalis pedis artery was observed after the 75 g glucose loading. There was a significant reduction in the
coronary flow reserve at 60 (4.06±0.75 vs. 3.54±0.82, p=0.021) and 90 minutes (4.06±0.75 vs. 3.59±0.63,
p=0.021) after the 75 g glucose loading compared to that on fasting. Conclusion: The results of this study suggest
that acute exposure to high circulating glucose levels does not affect heterogeneity of the ventricular repolarization
or arterial stiffness, but it does reduce the coronary flow reserve in healthy young men.

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