백단향추출물의 항산화, 항혈소판 응집 및 혈전 용해능에 관한 연구 (Preventive Effects of Santalum album L. Extracts on Oxidation, Platelet Aggregation and Thrombosis)

서지정보

· 발행기관 : 대한한방신경정신과학회
· 수록지 정보 : 동의신경정신과학회지 / 23권 / 1호 / 115 ~ 128페이지
· 저자명 : 송영위, 이지현, 송규주, 구병수, 김근우

초록

Objectives :To evaluate the in vitro scavenging activity, inhibitory effect of LDL oxidation of pro-oxidant reactive species,anti-platelet aggregative effects and anti-thrombosis effects in response to treatment with SA using various screening methods including biological and non-biological oxidants.
Methods :The antioxidant activity concerning extract from SA was studied with in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on Cu2+-induced human LDL oxidation and the inhibitory effect on thrombin-induced platelet aggregation and thrombosis.
Results :SA extracts were found to have a potent scavenging activity regarding oxidative stress as well as an inhibitory effect towards LDL oxidation, platelet aggregation, and thrombosis.
Conclusions :The SA extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drugs against oxidative stress and atherosclerosis.

영어초록

Objectives :To evaluate the in vitro scavenging activity, inhibitory effect of LDL oxidation of pro-oxidant reactive species,anti-platelet aggregative effects and anti-thrombosis effects in response to treatment with SA using various screening methods including biological and non-biological oxidants.
Methods :The antioxidant activity concerning extract from SA was studied with in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on Cu2+-induced human LDL oxidation and the inhibitory effect on thrombin-induced platelet aggregation and thrombosis.
Results :SA extracts were found to have a potent scavenging activity regarding oxidative stress as well as an inhibitory effect towards LDL oxidation, platelet aggregation, and thrombosis.
Conclusions :The SA extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drugs against oxidative stress and atherosclerosis.

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