桃仁이 중대뇌동맥 폐색 유발 흰쥐의 근육형태 변화와 혈관신생에 미치는 영향 (Muscle Type Change and Vascularization Effect of Semen Persicae in MCAo rats)

서지정보

· 발행기관 : 한방재활의학과학회
· 수록지 정보 : 한방재활의학과학회지 / 19권 / 1호 / 11 ~ 21페이지
· 저자명 : 권혁준, 소갑석, 김호준, 이명종

초록

Objectives :
This study was performed to investigate the effects of Semen Persicae(SP) on muscle type change and vascularization effect by measuring expression of Myosin heavy chain (MHC) and Vascular endothelial growth factor (VEGF) protein in the Middle cerebral artery occlusion(MCAo) rats.
Methods :
The middle cerebral artery was occluded, SP extraction was administrated for 4 days. The effects of SP on muscle type change and vascularization were measured.
Results :
1. VEGF protein expressions in the Semen Persicae oral administration group of MCAo group were increased compared to the control group.
2. There were no significant difference between the Semen Persicae oral administration of MCAo group and the control group in MHC isoform (Type I, Type IIa) expression change.
Conclusions :
The present study demonstrates the effect of Semen Persicae in the vascularizing after ischemia, but has no significant effect in musle type change and the improvement of musle atrophy.

영어초록

Objectives :
This study was performed to investigate the effects of Semen Persicae(SP) on muscle type change and vascularization effect by measuring expression of Myosin heavy chain (MHC) and Vascular endothelial growth factor (VEGF) protein in the Middle cerebral artery occlusion(MCAo) rats.
Methods :
The middle cerebral artery was occluded, SP extraction was administrated for 4 days. The effects of SP on muscle type change and vascularization were measured.
Results :
1. VEGF protein expressions in the Semen Persicae oral administration group of MCAo group were increased compared to the control group.
2. There were no significant difference between the Semen Persicae oral administration of MCAo group and the control group in MHC isoform (Type I, Type IIa) expression change.
Conclusions :
The present study demonstrates the effect of Semen Persicae in the vascularizing after ischemia, but has no significant effect in musle type change and the improvement of musle atrophy.

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