뇌졸중 중증도 예측 시 Multimarker IndexTM의 유용성 평가 (Availability of Multimarker IndexTM in Prediction of Ischemic Stroke Severity)

서지정보

· 발행기관 : 대한응급의학회
· 수록지 정보 : 대한응급의학회지 / 19권 / 5호 / 551 ~ 556페이지
· 저자명 : 강진아, 김강호, 김지혜, 한승백, 김준식, 이경미, 김훈

초록

Purpose: The Multimarker IndexTM (MMX) is derived from
4 biochemical markers (S100 β, MMP-9, D-dimer, BNP)
and is known to be useful in the early detection of stroke.
Assessment of severity in the early stages of stroke is as
important as early detection of stroke itself, so that early
intensive management can be applied. We evaluated
wheather MMX is correlated with stroke severity as measured
by NIHSS.
Methods: MRI-confirmed stroke patients were prospectively
enrolled for analysis of MMX from their serum, and initial
NIHSS was recorded. Patients were divided into three convenient
groups according to the time from symptom onset.
In each group, correlation of MMX and NIHSS was studied.
Results: Fifty-one patients were enrolled, and MMX was
found to be positively correlated with NIHSS (p<0.01). In
subgroup analysis, group A (presented to ED within 6 hours
of symptom onset), and group B (presented to ED from 6-
12 hours after symptom onset) showed the same positive
correlation between MMX and NIHSS (p=0.017, p<0.001),
but in group C (presented to ED after more than 12 hours
after symptom onset), there was no correlation (p=0.840).
Conclusion: MMX positively correlated with stroke severity
measured by NIHSS for patients presenting to ED within 12
hours of symptom onset.

영어초록

Purpose: The Multimarker IndexTM (MMX) is derived from
4 biochemical markers (S100 β, MMP-9, D-dimer, BNP)
and is known to be useful in the early detection of stroke.
Assessment of severity in the early stages of stroke is as
important as early detection of stroke itself, so that early
intensive management can be applied. We evaluated
wheather MMX is correlated with stroke severity as measured
by NIHSS.
Methods: MRI-confirmed stroke patients were prospectively
enrolled for analysis of MMX from their serum, and initial
NIHSS was recorded. Patients were divided into three convenient
groups according to the time from symptom onset.
In each group, correlation of MMX and NIHSS was studied.
Results: Fifty-one patients were enrolled, and MMX was
found to be positively correlated with NIHSS (p<0.01). In
subgroup analysis, group A (presented to ED within 6 hours
of symptom onset), and group B (presented to ED from 6-
12 hours after symptom onset) showed the same positive
correlation between MMX and NIHSS (p=0.017, p<0.001),
but in group C (presented to ED after more than 12 hours
after symptom onset), there was no correlation (p=0.840).
Conclusion: MMX positively correlated with stroke severity
measured by NIHSS for patients presenting to ED within 12
hours of symptom onset.

참고자료

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