양극산화 표면처리한 티타늄 임플랜트를 난소절제한 백서 경골에 매식 후 주위 골형성에 관한 연구 (The bone formation around anodic oxidized titanium implants in the tinbiae of ovarectomized rats)

서지정보

· 발행기관 : 대한구강악안면외과학회
· 수록지 정보 : 대한구강악안면외과학회지 / 34권 / 3호 / 306 ~ 318페이지
· 저자명 : 박성환, 정석영, 이재열, 김규천, 신상훈

초록

Anodic spark deposition method(ASD) surface treated titanium implant possesses a considerable osteoconductive potential that promoting a high
level of implant osseointegration in normal bone.
The purpose of this study was to observe the ASD implant's osseointegration in the osteoporosis-induced animal model. Twenty four rats, 10 weeks
of age, were ovarectomized and 5 weeks later divided into two groups : ASD implant group and control implant group. Titanium screw implants
(diameter; 2.0 ㎜, length, 3.5 ㎜; pitch-height, 0.4 ㎜) were designed for this study. Experimental implants were ASD treated and no treatment on control
implants. ASD implants and control implants were placed in to left tibiae of rats. The rats were sacrificed at different time interval(1, 2, 4 and 8
weeks after implantation) for histopathologic observation and immunohisto -chemistrical observation, with collagen type Ⅰ, fibronectin, integrin α2β1
and integrin α5β1 antibodies.
The results obtained from this study were as follow:
1. Histopathologic findings, overall tissue response and the pattern of bone formation in both groups were similar. In ASD group, more newly
formed bone was seen at 1 week and 2weeks than control group.
2. The levels of type Ⅰ collagen and fibronectin expression were the most abundant at 2weeks and decreased gradually in both groups. Fibronectin
and type Ⅰ collagen expression in ASD group were stronger than control group but no significance.
3. The levels of integrin α2β1 and Integrin α5β1 expression were most abundant at 2 weeks and decreased gradually in both groups. No significant
difference was observed in both groups.
From this results, anodic oxidized titanium implants were more advantages in early stage of bone formation than control group, but have no significance
in tissue responses and late bone formations.
It could be stated that although anodic oxidized titanium implant possesses considerable osteoconductive potential but in osteoporotic bone condition
dental implant procedure should performed after improving or treating the osteoporotic bone condition.

영어초록

Anodic spark deposition method(ASD) surface treated titanium implant possesses a considerable osteoconductive potential that promoting a high
level of implant osseointegration in normal bone.
The purpose of this study was to observe the ASD implant's osseointegration in the osteoporosis-induced animal model. Twenty four rats, 10 weeks
of age, were ovarectomized and 5 weeks later divided into two groups : ASD implant group and control implant group. Titanium screw implants
(diameter; 2.0 ㎜, length, 3.5 ㎜; pitch-height, 0.4 ㎜) were designed for this study. Experimental implants were ASD treated and no treatment on control
implants. ASD implants and control implants were placed in to left tibiae of rats. The rats were sacrificed at different time interval(1, 2, 4 and 8
weeks after implantation) for histopathologic observation and immunohisto -chemistrical observation, with collagen type Ⅰ, fibronectin, integrin α2β1
and integrin α5β1 antibodies.
The results obtained from this study were as follow:
1. Histopathologic findings, overall tissue response and the pattern of bone formation in both groups were similar. In ASD group, more newly
formed bone was seen at 1 week and 2weeks than control group.
2. The levels of type Ⅰ collagen and fibronectin expression were the most abundant at 2weeks and decreased gradually in both groups. Fibronectin
and type Ⅰ collagen expression in ASD group were stronger than control group but no significance.
3. The levels of integrin α2β1 and Integrin α5β1 expression were most abundant at 2 weeks and decreased gradually in both groups. No significant
difference was observed in both groups.
From this results, anodic oxidized titanium implants were more advantages in early stage of bone formation than control group, but have no significance
in tissue responses and late bone formations.
It could be stated that although anodic oxidized titanium implant possesses considerable osteoconductive potential but in osteoporotic bone condition
dental implant procedure should performed after improving or treating the osteoporotic bone condition.

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