체중 부하 운동이 흰쥐의 골대사에 미치는 영향 (The Effects of Erect Bipedal Stance Exercise on Bone Formation and Resorption in Rats)

서지정보

· 발행기관 : 한국영양학회
· 수록지 정보 : Journal of Nutrition and Health / 39권 / 2호 / 109 ~ 114페이지
· 저자명 : 홍희옥, 맹원재

초록

본 연구는 본 연구자가 고안한 erect bipedal stance ex -ercise 장치를 이용하여 저항운동이 흰쥐의 골대사와 골질량에 미치는 영향을 알아보기 위하여 수컷 Sprague Daw-ley를 이용하여 13주간 실험을 하였으며 그 결과를 요약하면 다음과 같다. 식이섭취량은 각 실험군들에서 비슷한 수준을 나타냈으나 실험 종료 시 체중과 체중 증가량은 control군이 exercise군에 비해 유의적으로 높았다. 골질량은 앞다리의 경우 control군이 exercise군보다 다소 높았으나 뒷다리의 경우 exercise군이 control군보다 약간 높았으며 뼈의 길이는 ulna를 제외한 나머지 부위가 ex-ercise군에 비하여 control군이 유의적으로 길었다. Femur과 tibia의 체중 당으로 환산한 골질량과 강도는 exercise군이 control군에 비하여 유의적으로 높았으며 femur과 ti-bia의 회분 함량 및 칼슘과 인의 함량도 exercise군이 유의적으로 높았다. 골형성의 biomarker인 osteocalcin 농도는 exercise군이 control군에 비하여 유의적으로 높았으며 B-ALP활성도는 control군에 비하여 다소 높게 나타났다. 반면에 골용출의 biomarker인 뇨중 DPD농도는 exercise군에서 유의적으로 낮았다.

영어초록

The effects of the erect bipedal stance exercise on bone mass and the biomarkers of bone formation and resorption were investigated in rats. Five-week old rats were assigned into control and exercise groups. The rats of exercise group were weight-bearing-trained for 13 weeks in the cage designed to adjust progressively the height from 26.5 cm to 31.5 cm to force the rats rising an erect bipedal stance for feeding and drinking. There was no significant difference in food intakes between two groups. But body weight gain was significantly increased in control group. The lengths of femur, tibia, humerus and radius were significantly longer in control group than exercise group, but the femur and tibia weights per body weight were significantly higher in exercise group than control group. Also the breaking force of femur and tibia in exercise group were higher than control group significantly. The calcium contents of femur and tibia were significantly increased in exercise group than control group. The activity of bone specific alkaline phosphatase (B-ALP) and the osteocalcin contents of serum (the biomarkers of bone formation) in exercise group were higher than control group, but the carboxyterminal propeptide of type I procollagen (P1CP) contents of serum did not show any difference between two groups. However the urinary deoxypridinolin (DPD) excretion, biomarker of bone resorption, was significantly lower in exercise group than control group. From these results, it has been indicated that the erect bipedal stance exercise enhanced the density and the strength of femur and tibia by increasing biomarkers of bone formation and suppressing a biomarker of bone resorption in rats.

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