The Harmful Effects of Prolonged Strenuous Treadmill Exercise on Bronchoalveolar System in Rats

서지정보

· 발행기관 : 한국생명과학회
· 수록지 정보 : 생명과학회지 / 19권 / 10호 / 1352 ~ 1359페이지
· 저자명 : 오경모, 현경예, 김치영, 최석철, 신군수

초록

We designed this study to investigate the effects of continuous strenuous aerobic exercise on the respiratory system in a rat model. After exercise for 8 weeks, rats' weights were higher in the exercise groups than in the Control group (non-exercise). Rats in Exercise-120 min group (Ex-120 group) had the lowest weights. Total leukocyte counts in bronchoalveolar lavage fluid (BALF) were higher in exercise groups than in Control group. The Ex-30 and Ex-120 groups had higher neutrophil counts, whereas that in the Ex-60 group was lower than in the Control group, and that in the Ex-30 group was the highest. Lymphocyte and monocyte counts were higher in all exercise groups than in the Control group, and those in the Exercise-120 min group were the highest. Interleukin-6 (IL-6) level was the highest, while IL-10, interferon-γ and nitric oxide (NO) levels were the lowest in the Ex-120 group when compared to the Control and other exercise groups. These findings suggest that strenuous aerobic exercise for short periods (30 min) may have a beneficial effect on decrease in body weight, whereas prolonged-strenuous aerobic exercise (＞1 hr) may be adverse to leukocyte and immune levels in the bronchoalveolar system, as well as result in an increased production of oxygen free radicals.

참고자료

· 없음