자궁근종에 대한 GnRH agonist 치료에 따른 효과 -임상적 효용 및 전자현미경적 연구- (Effect of GnRH agoinst Treatment on Leiomyoma -A study on the clinical effect and ultrastructural changes-)

서지정보

· 발행기관 : 고신대학교(의대) 고신대학교 의과대학 학술지
· 수록지 정보 : 고신대학교 의과대학 학술지 / 9권 / 1호 / 71 ~ 80페이지
· 저자명 : 김흥열, 박은동, 장희경, 허만하

초록

-Abstract- Administration of gonadotropin hormone-releasing hormone(GnRH) agonist, through a process of pituitary desensitization and down-regulation of receptors, inhibits the secretion of gonadotropin and sex-steroids and induces a reversible suppression of gonadal activity. This approach can be used as an effective endocrine therapy for some hormone-dependent tumors. We have used GnRH agonist, for the treatment of four patients with uterine leiomyomas, thereafter myometomy was performed in all cases.
To assess the effect of treatment with GnRH agonist, ultrastructural changes of the tumor cells of leiomyoma are studied, along with measurement of changes in serum hormone levels(LH, FSH, and E2) and the sizes of the neoplasm.
Electron microscopic findings of myoma cells after the use of GnRH agonist included the following : increased mitochondria, swelling of mitochondria with loss of cristae, clumping of nuclear chromatin, dilation of endoplasmic reticulum and perinuclear vacuolation, and loss of myofilaments.
The use of GnRH agonist may be effective in reducing the size of a myoma considerably by primarily inducing medical hypophysectomy and would allow easier surgical removal.

영어초록

-Abstract- Administration of gonadotropin hormone-releasing hormone(GnRH) agonist, through a process of pituitary desensitization and down-regulation of receptors, inhibits the secretion of gonadotropin and sex-steroids and induces a reversible suppression of gonadal activity. This approach can be used as an effective endocrine therapy for some hormone-dependent tumors. We have used GnRH agonist, for the treatment of four patients with uterine leiomyomas, thereafter myometomy was performed in all cases.
To assess the effect of treatment with GnRH agonist, ultrastructural changes of the tumor cells of leiomyoma are studied, along with measurement of changes in serum hormone levels(LH, FSH, and E2) and the sizes of the neoplasm.
Electron microscopic findings of myoma cells after the use of GnRH agonist included the following : increased mitochondria, swelling of mitochondria with loss of cristae, clumping of nuclear chromatin, dilation of endoplasmic reticulum and perinuclear vacuolation, and loss of myofilaments.
The use of GnRH agonist may be effective in reducing the size of a myoma considerably by primarily inducing medical hypophysectomy and would allow easier surgical removal.

참고자료

· 없음