결명자의 타크린으로 유발한 간 세포독성 보호 성분 (Hepatoprotective compounds of Cassiae Semen on tacrine-inducedcytotoxicity in Hep G2 cells)

서지정보

· 발행기관 : 한국생약학회
· 수록지 정보 : 생약학회지 / 38권 / 4호 / 400 ~ 402페이지
· 저자명 : 변에리사, 정길생, 안인파, 리빈, 이동성, 고은경, 윤권하, 김윤철

초록

is an acetylcholinesterase inhibitor that is approved for the treatment of Alzheimer’s disease. However,tacrine treatment for Alzheimer’s disease results in reversible hepatotoxicity in 30-50% of patients, which seriously limits itsclinical use. Accordingly, the identification of constituents in natural products that have protective efects on tacrine-inducedhepatotoxicity would be valuable. In the present study, an immortalized human hepatoma cell line, HepG2 was employed toscreen for agents that protect against tacrine-induced hepatotoxicity. The bioassay-guided fractionation of water extract of Cas-siae Semen furnished two anthraquinones, aurantio-obtusin (1) and obtusifolin (2). Compounds 1 and 2 showed hepato-protective effects with the protection ratio values of 55.3 +/ 0.5% and 41.2 +/ 0.8% at 160M, respectively.Key words Cassia obtusifolia L, aurantio-obtusin, obtusifolin, tacrine, hepatoprotection, HepG2

영어초록

is an acetylcholinesterase inhibitor that is approved for the treatment of Alzheimer’s disease. However,tacrine treatment for Alzheimer’s disease results in reversible hepatotoxicity in 30-50% of patients, which seriously limits itsclinical use. Accordingly, the identification of constituents in natural products that have protective efects on tacrine-inducedhepatotoxicity would be valuable. In the present study, an immortalized human hepatoma cell line, HepG2 was employed toscreen for agents that protect against tacrine-induced hepatotoxicity. The bioassay-guided fractionation of water extract of Cas-siae Semen furnished two anthraquinones, aurantio-obtusin (1) and obtusifolin (2). Compounds 1 and 2 showed hepato-protective effects with the protection ratio values of 55.3 +/ 0.5% and 41.2 +/ 0.8% at 160M, respectively.Key words Cassia obtusifolia L, aurantio-obtusin, obtusifolin, tacrine, hepatoprotection, HepG2

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