ABO 혈액형 부적합 신장이식 환자에서혈연 간 신장이식과 비혈연 간 신장이식의 성적 비교 (Clinical Outcomes between Living Related and Living Unrelated Kidney Transplantation in ABO-Incompatible Kidney Transplant Recipients)

서지정보

· 발행기관 : 대한내과학회
· 수록지 정보 : 대한내과학회지 / 87권 / 6호 / 698 ~ 704페이지
· 저자명 : 박우영, 한승엽, 황은아, 박성배, 박의준, 김형태, 조원현

초록

Background/Aims: Kidney transplantation (KT) is the best treatment for end-stage renal disease patients. Although previousstudies have demonstrated that the clinical outcome following living related (LR) KT is better than that following unrelated (LUR)KT in ABO-compatible KT recipients, recent studies showed no differences in clinical outcomes between the two treatments. Inthis study, we compared the clinical outcomes of LR and LUR KT in ABO-incompatible KT recipients.
Methods: From January 2011 to August 2013, 19 cases of ABO-incompatible KT were analyzed retrospectively. Eight kidneys (7cases of parent-offspring and 1 case of siblings, Group 1) were donated from living-related donors and 11 (all spousal donors,Group 2) from living-unrelated donors. We investigated patient survival, graft survival, acute rejection, graft function, and complications.
Results: On Kaplan-Meier analysis, patient and graft survival during follow-up were 87.5% and 87.5% in Group 1; both were100% in Group 2. Acute rejection, graft function, and medical and surgical complications were not significantly different betweenthe two groups.
Conclusions: The short-term clinical outcomes between LR and LUR KT in ABO-incompatible KT recipients were equivalent. Most domestic cases of LUR KT are from spousal donors and the spousal donor will be a major donor in ABO-incompatible KT patients.

영어초록

Background/Aims: Kidney transplantation (KT) is the best treatment for end-stage renal disease patients. Although previousstudies have demonstrated that the clinical outcome following living related (LR) KT is better than that following unrelated (LUR)KT in ABO-compatible KT recipients, recent studies showed no differences in clinical outcomes between the two treatments. Inthis study, we compared the clinical outcomes of LR and LUR KT in ABO-incompatible KT recipients.
Methods: From January 2011 to August 2013, 19 cases of ABO-incompatible KT were analyzed retrospectively. Eight kidneys (7cases of parent-offspring and 1 case of siblings, Group 1) were donated from living-related donors and 11 (all spousal donors,Group 2) from living-unrelated donors. We investigated patient survival, graft survival, acute rejection, graft function, and complications.
Results: On Kaplan-Meier analysis, patient and graft survival during follow-up were 87.5% and 87.5% in Group 1; both were100% in Group 2. Acute rejection, graft function, and medical and surgical complications were not significantly different betweenthe two groups.
Conclusions: The short-term clinical outcomes between LR and LUR KT in ABO-incompatible KT recipients were equivalent. Most domestic cases of LUR KT are from spousal donors and the spousal donor will be a major donor in ABO-incompatible KT patients.

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