Voxel-based Investigations of Phase Mask Effects on Susceptibility Weighted Images

서지정보

· 발행기관 : 한국의학물리학회
· 수록지 정보 : 의학물리 / 24권 / 1호 / 25 ~ 34페이지
· 저자명 : 황어진, 김민지, 김혁기, 류창우, 장건호

초록

To investigate effects of phase mask on susceptibility-weighted images (SWI) using voxel-based analyses innormal elderly subjects. A three-dimensional (3D) gradient echo sequence ran to obtain SWIs in 20 healthy elderlysubjects. SWIs with two (SWI2) and four (SWI4) phase multiplications were achieved with positive (PSWI) andnegative (NSWI) phase masks to investigate phase mask effects. The voxel-based comparisons were performedusing paired t-tests between PSWI and NSWI and between SWI2 and SWI4. Differences of signal intensitiesbetween magnitude images and SWI4 were larger than those between magnitude images and SWI2s. Differencesof signal intensities between magnitude images and PSWIs were larger than those between magnitude imagesand NSWIs. Moreover, the signal intensities from NSWI2s and NSWI4s were greater than those from PSWI2s andPSWI4s, respectively. More differences of signal intensities between NSWI4 and PSWI4s were found than thosebetween NSWI2s and PSWI2s in the whole brain images. The voxel-based analyses of SWI could be beneficialto investigate susceptibility differences on the entire brain areas. The phase masking method could be chosento enhance brain tissue contrast rather than to enhance venous blood vessels. Therefore, it is recommendedto apply voxel-based analyses of SWI to investigate clinical applications.

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