유도선수의 미토콘드리아 DNA 3316G/A 다형성이 철분대사 변인에 미치는 영향 (Influences of the 3316G/A Polymorphism in the Mitochondrial DNA on Iron Parameters in Male Judo Players)

서지정보

· 발행기관 : 한국체육과학회
· 수록지 정보 : 한국체육과학회지 / 18권 / 1호 / 923 ~ 931페이지
· 저자명 : 신혜정, 강병용, 정인근, 이재구

초록

Mitochondria includes the circular DNA molecules, and the genes in the mitochondrial DNA(mtDNA) are those of the candidates associated with iron metabolism . In this study, we examined the distribution of the 3316G/A polymorphism in the mtDNA between normal controls and judo players, respectively, and compared the influence of this polymorphism on iron metabolism in the both groups. Blood iron parameters were assayed by automatic analyzer, and the 3316G/A polymorphism in the mtDNA analyzed by polymerase chain reaction(PCR) and HaeIII restriction fragment length polymorphism(RFLP) methods. With respect to iron parameters, there were significant differences in several iron parameters between two groups(p<.05). Especially, judo players indicated significantly lower red blood cell(RBC) count, hematocrit, serum iron and transferrin levels compared with normal controls, respectively. Also the A allele of the 3316G/A polymorphism in the mtDNA was only observed in judo players , and this allele significantly associated with serum haptoglobin level in this group(p<.05). Reasonable mechanism for the this association will be identified through further studies.

영어초록

Mitochondria includes the circular DNA molecules, and the genes in the mitochondrial DNA(mtDNA) are those of the candidates associated with iron metabolism . In this study, we examined the distribution of the 3316G/A polymorphism in the mtDNA between normal controls and judo players, respectively, and compared the influence of this polymorphism on iron metabolism in the both groups. Blood iron parameters were assayed by automatic analyzer, and the 3316G/A polymorphism in the mtDNA analyzed by polymerase chain reaction(PCR) and HaeIII restriction fragment length polymorphism(RFLP) methods. With respect to iron parameters, there were significant differences in several iron parameters between two groups(p<.05). Especially, judo players indicated significantly lower red blood cell(RBC) count, hematocrit, serum iron and transferrin levels compared with normal controls, respectively. Also the A allele of the 3316G/A polymorphism in the mtDNA was only observed in judo players , and this allele significantly associated with serum haptoglobin level in this group(p<.05). Reasonable mechanism for the this association will be identified through further studies.

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