New conceptual approaches toward dentin regeneration using the drug repositioning strategy with Wnt signaling pathways

서지정보

· 발행기관 : 대한구강생물학회
· 수록지 정보 : International Journal of Oral Biology / 46권 / 2호
· 저자명 : Eui-Seon Lee, Tae-Young Kim, Yam Prasad Aryal, Kihyun Kim, Seongsoo Byun, Dongju Song, Yejin Shin, Dany Lee, Jooheon Lee, Gilyoung Jung, Seunghoon Chi, Yoolim Choi, Youngkyun Lee, Chang-Hyeon An, Jae-Young Kim

목차

Structure and Function of Dentin
Wnt Signalings in Tooth Formation
Recent Studies in RegenerativeEndodontics
1. Cell transplantation and homing
2. Pulp revascularization
3. Tertiary dentin formation using Wnt/β-cateninsignaling
4. Reparative dentin formation using drugrepositioning
Conclusions
References

영어초록

This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs for dentin regeneration has been discussed in this study.

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