보문 : HMG-CoA Reductase의 저해제 탐색과 가금의 콜레스테롤 저하 효과

서지정보

· 발행기관 : 한국식품영양학회
· 수록지 정보 : 한국식품영양학회지 / 15권 / 4호
· 저자명 : 이은숙, 이준우

초록

체내 cholesterol 수치를 낮추기 위하여 HMG-CoA reductase 활성을 저해하는 물질들을 닭에게 급여하여 in vitro상에서 검토한 결과, HMG-CoA reductase 활성에 대한 마늘, lovastatin과 copper의 순으로 저해능은 51.3%, 87.5%, 82.0%이었다. 또한 혈장, 가슴조직, 간장의 cholesterol 함량에 대한 마늘 (3% in diet), lovastatin (300mg/kg of diet), copper (200 mg/kg of diet)의 효과를 검토하였다. 혈장 중의 cholesterol 함량과 HDL. LDL cholesterol 함량은 3% 마늘의 투여로 감소되어졌으나 copper의 투여는 오히려 증가하였고, lovastatin 투여에 의한 차이는 나타나지 않았다. 그리고 간장과 가슴조직의 cholesterol 과 triglyceride는 사료에 cholesterol의 수치를 저하시키는 물질을 첨가하였으나 별다른 차이가 없었다

영어초록

The primary objective of these studies was to screen the materials showing inhibitions of HMG-CoA reductase in vitro. The secondary objective was to determine the effect of garlic, lovastatin and copper on cholesterol concentrations in plasma, liver and breast tissues in pullets. The degree of inhibition of the selective samples on HMG-CoA reductase activity was determined in vitro. The inhibition ratios of water soluble garlic extracts, lovastatin (methanol extracts) and copper to HMG-CoA reductase activity were 51.3%, 87.5%, and 82.0%, respectively. Control diet (basal diet) and experimental diets, garlic powder (3% in diet), lovastatin (300 mg/kg of diet) and copper (200 mg/Kg of diet) and experimental diets, garlic powder (3% in diet), lovastatin (300mg/Kg of diet) and copper (200 mg/Kg of diet) were fed to pullets in order to investigate the changes of cholesterol concentration in plasma and tissues. Total cholesterol, HDL- and LDL-cholesterol in blood plasma were significantly reduced in pullets fed diet containing 3% garlic powder. However, copper significantly increased total cholesterol compared to control and lovastatin did not affect plasma cholesterol concentration. Total cholesterol and triglyceride of liver and breast tissues in pullets were not affected by adding the cholesterol-lowering materials to diets. the data suggests that it is not easy for HMG-CoA reductase inhibitors cholesterol-lowering materials to diets. The data suggests that it is not easy for HMG-CoA reductase inhibitors to reduce cholesterol levels in body due to complication of cholesterol metabolism. However, garlic administration can lower the levels of plasma cholesterol in pullets.

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