Induction of IL-6 and IL-8 Expression by Leptin Treatment in Periodontal Ligament Cells and Gingival Fibroblasts
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ㆍ발행기관 : 대한구강생물학회
ㆍ수록지정보 : International Journal of Oral Biology / 38권 / 2호
ㆍ저자명 : Hong-Gyu Park, Ji-Hye Kim, Jeong-Heon Cha, Eun-Jung Bak, Yun-Jung Yoo
영어 초록
Leptin is one of the adipocytokines produced from adi- pose tissue but its functions in periodontal tissue have not previously been investigated. In our current study, we exa- mined the effects of leptin on the expression of interleukin (IL)-6 and IL-8 in periodontal ligament (PDL) cells and gingival fibroblasts. Leptin receptor expression was evalua- ted by RT-PCR and the production of cytokines was mea- sured by ELISA. The phosphorylation of Akt and Erk1/2 was assessed by western blotting. mRNA of long and short form leptin receptors were detected in both PDL cells and gingival fibroblasts. Leptin was found to increase the pro- duction of IL-6 and IL-8 in both of these cell types, an effect which was not blocked by polymyxin B, an inhibitor of lipopolysaccharide (LPS). Leptin did not alter the pro- duction of IL-6 and IL-8 induced by LPS in PDL cells but increased Akt and Erk1/2 phosphorylation in these cells. These results suggest that leptin acts as an inducer of IL-6 and IL-8 in PDL cells and gingival fibroblasts.
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