종양의 뇌 전이 (Brain metastasis)

소개글

종양의 뇌 전이 (Brain metastasis)에 대해 Harrison을 비롯한 인터넷 문헌, 논문 등을 참고하여 종합한 발표용 북리뷰입니다.

목차

Lung cancer
Mechanisms of Brain Metastases
Clinical Features
Imaging study
Laboratory Examination
Without Known Primary Tumor
Treatment
Reference

본문내용

* Mechanisms of Brain Metastases
전이 기전 : Hematogenous spread

호발 부위
Gray matter–white matter junction
Border zone between middle & posterior cerebral artery distributions

*Clinical Features
Usually present with one of 3 syndromes
Subacute progression of a focal neurologic deficit
Seizure
Non-focal neurologic disorder
: Headache, Dementia, Personality change, Gait disorder

Systemic symptoms
Malaise
Weight loss
Anorexia
Fever
 Metastatic lesion > Primary brain tumor

참고 자료

Harrison’s principles of internal medicine, Fauci et al., McGraw-Hill, 2008, 17th.
Cecil medicine, Goldman & Ausiello, Elsevier, 2008, 23rd.
NCCN practice guideline in oncology.
Klos & O’Neil, Brain Metastases, The Neurologist, 2004;10(1): 31-46.
Victor Tse, Brain Metastasis, Emedicine, Nov 10, 2009.
(http://emedicine.medscape.com/article/1157902-overview)