편백 정유의 마우스에 대한 급성경구독성
(주)코리아스칼라
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- 2023.04.05
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- 2018.06
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서지정보
ㆍ발행기관 : 한국식품위생안전성학회
ㆍ수록지정보 : 한국식품위생안전성학회지 / 33권 / 3호
ㆍ저자명 : 임창우, 손송이, 이후장
목차
ABSTRACT
Materials and Methods
공시제제
실험동물
시험물질 투여
일반 중독증상 및 치사 동물수 관찰
체중 측정
혈액학적·혈액생화학적 분석
부검 및 LD50산출
통계학적 분석
Results
일반 중독증상 및 치사 동물수
체중 변화
혈액학적·혈액생화학적 분석
부검소견 및 LD50값
Discussion
국문요약
References
영어 초록
The present study was carried out to investigate the acute oral toxicity of Chamaecyparis obtusa (C. obtusa) essential oil in ICR male and female mice. Acute oral treatment with C. obtusa essential oil did not reveal any sign of toxicity or mortality in treated mice. Mouse body weights were not affected after single oral administration of C. obtusa essential oil during the 14-day observation period. In the hematological and blood biochemical analysis, all parameters of the treated group with 2,000 mg/kg body weight of the essential oil were not significantly different those of the control group. Therefore, the lethal dose 50 of the essential oil was estimated to be greater than 2,000 mg/ kg body weight in mice, which indicated that the essential oil is non-toxic. In conclusion, this study suggests that C. obtusa essential oil orally safe ICR mice.
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