RHEUMATOID ARTHRITIS

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RHEUMATOID ARTHRITIS

INTRODUCTION
EPIDEMIOLOGY AND GENETICS
ETIOLOGY
PATHOLOGY AND PATHOGENESIS
CLINICAL MANIFESTATIONS
LABORATORY FINDINGS
RADIOGRAPHIC EVALUATION
CLINICAL COURSE AND PROGNOSIS
DIAGNOSIS
TREATMENT

본문내용

RHEUMATOID ARTHRITIS

INTRODUCTION
Rheumatoid arthritis (RA)
chronic multisystem disease of unknown cause.
persistent inflammatory synovitis, usually involving peripheral joints in a symmetric distribution.
cartilage damage and bone erosions and subsequent changes in joint integrity

EPIDEMIOLOGY AND GENETICS
prevalence : 약 0.8% of the population (range 0.3 to 2.1%); 여성은 남성의 3배
유병율은 고령에서 증가 그리고 성 차이는 older age group에서 감소.
전 세계적으로 모든 인종에서 나타나나 인종적 차이는 존재.
onset is most frequent during the fourth and fifth decades of life
80% of all patients developing the disease between the ages of 35 and 50.
최근 유병율이 줄고 있음
two HLA-DRB1 alleles 는 RA와 연관됨.
HLA-DR4 (DRB*0401) 는 RA의 major genetic risk factors.(일반인 28%양성, RA 환자는 70% 양성)
early aggressive disease and extraarticular manifestations DRB*0401, DRB*0404
more slowly progressive disease in those with DRB*0101.
TNF 와 IL 10 genes 도 RA와 관련 있음
환경도 영향을 미침.

참고 자료

Harrison`s Principles of Internal Medicine 16th Edition : 301. RHEUMATOID ARTHRITIS - Peter E. Lipsky