4-Nitroquinoline 1-Oxide에 대한 유산균의 항돌연변이 효과

서지정보

ㆍ발행기관 : 한국유산균학회 ㆍ수록지정보 : Current Topic in Lactic Acid Bacteria and Probiotics / 3권 / 1호
ㆍ저자명 : 송수연, 정종욱, 김광현, 박동준, 오세종

목차

서 론
재료 및 방법
유산균
돌연변이 유발 물질
Salmonella Typhimurium TA100
Salmonella Typhimurium TA100의 유전형질 확인
S9 Mixture 제조
항돌연변이 활성 평가
결과 및 고찰
요 약
참고문헌

영어 초록

Intestinal lactic acid bacteria (LAB) for humans are closely associated to the host’s health because the presenceof LAB is an important bio-defense factor in preventing colonization and subsequent proliferation of pathogenic bacteria inthe intestine. Some probiotics such as Lactobacillus species can intoxication of carcinogens including chemical mutagens.The purpose of this study was to compare the ability of antimutagenesity among 24 strains of LAB isolated from infantfeces, yogurt and kimchi etc. The antimutagenic effects of protein fractions extracted from the cells of 24 LAB strains wereinvestigated using mutagens as 4-nitroquinoline-N'-oxide in Ames test (Salmonella Typhimurium TA 100). In the Amestest, dose-dependent activity was exhibited significantly against 4NQO. Three strains of Lactobacillus showed the highestanti-4NQO activitiy (62.1%) among the tested strains of LAB.

참고 자료

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