카이스트 Bioengineering Laboratory 1 lab3_prelab [protein structure prediction]

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카이스트 바이오및뇌공학과 계측 1 실험 3 prelab 보고서 입니다
한글자료입니다
14년도 1학기 전체 1등으로 A+ 받았습니다.

목차

1. What is comparative structure modeling (homology modeling) of a protein?
Discuss about the importance of protein structure prediction
2. Study and explain about following terms.
: local alignment, global alignment, domain of protein, secondary structure of protein, pdb file format
3. Compare two alignment methods. What is the difference between local alignment and global alignment. Write about pros and cons about each alignment by mentioning certain protein structure modeling situations.
4. Discuss about the factors you can consider when you are selecting appropriate templates for protein structure modeling. Choose your answer for the best template pdb and describe the reasons.

본문내용

1. What is comparative structure modeling (homology modeling) of a protein?
Discuss about the importance of protein structure prediction
Homology modeling이란 주어진 amino acid sequence를 통해 단백질의 3-dimensional tertiary structure를 예측하는 방법이다. 주어진 단백질 아미노산 서열(query sequence)과 유사한 몇 개의 다른 단백질의 서열 (template sequence)을 찾고 비교하여 query sequence의 구조를 예측한다. Homology modeling 방법에는 크게 fragment-based method와 restraint-based method가 있다.

참고 자료

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