colorectal carcinogenesis

소개글

"colorectal carcinogenesis"에 대한 내용입니다.

목차

1. Colorectal carcinogenesis
1) Mechanisms of carcinogenesis
2) Chromosomal instability (CIN)
3) CpG island methylator phenotype(CIMP)
4) microsatellite instability (MSI)

2. Colorectal cancer의 risk factor
1) Hereditary CRC syndromes
2) Personal or family history of sporadic CRCs or adenomatous polyps
3) Inflammatory bowel disease
4) 다른 요소들

본문내용

세계적으로 colorectal cancer (CRC) 는 여성에게는 the second most common cancer, 남성에게는 the third most common cancer 로 알려져 있으며 국내의 경우 여성의 the third most common cancer, 남성의 the second most common cancer로 조사 되어 있다.
1) Mechanisms of carcinogenesis
CRCs 는 chromosomal instability (CIN), CpG island methylator phenotype (CIMP), 그리고 microsatellite instability (MSI) 의 different mechanisms 의 하나 혹은 조합에 의해 발생한다.
2) Chromosomal instability (CIN)
Chromosomal instability 는 sporadic CRCs 의 65%-70%와 관련이 있다.
classical CIN pathway는adenomatous polyposis coli (APC) 의 mutations 의 획득으로 시작하여 oncogene KRAS 의 mutational activation 과 tumor suppressor gene, TP53. 의 inactivation 이 이어서 나타난다. Aneuploidy and loss of heterozygosity (LOH) 가 CIN 의 major players 이다.

참고 자료

Kanwal Tariq, KulsoomGhias. Colorectal cancer carcinogenesis: a review of mechanismsCancer Biol Med. 2016 Mar; 13(1): 120–135.
Hans Raskov, Hans-Christian Pommergaardet all. Colorectal carcinogenesis-update and perspectives. World J Gastroenterol. 2014 Dec 28; 20(48): 18151–18164
Zhao Y, Ando K, Oki E, Ikawa-Yoshida A, Ida S, Kimura Y, et al. Aberrations of BUBR1 and TP53 gene mutually associated with chromosomal instability in human colorectal cancer. Anticancer Res. 2014;34: 5421–7.
Finlay A Macrae, MD. Colorectal cancer: Epidemiology, risk factors, and protective factors
UpToDate Apr 27, 2020.
Ward EM, Sherman RL, Henley SJ, et al. Annual Report to the Nation on the Status of Cancer, Featuring Cancer in Men and Women Age 20-49 Years. J Natl Cancer Inst 2019; 111:1279.
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