Dendrimers

목차

Definition
Preparation(Synthesis)
Characteristics
Applications
Conclusion
References

본문내용

emanating from a central core.
The number of branch points increases upon moving from the dendrimer core to its surface and defines dendrimer generation.
Preparation
(PAMAM dendrimer generation)
Structure
Main architectural components
Core- a starting unit with 3 covalent root attachment points
Branches- monomer units with three functionalities
Surface group(end group)- Dense presentation of multiple terminal groups on surface
Void spaces- Core-shell molecular architecture with chemically distinct interior and surface.
Generations
Dendrimers are constructed through a set of repeating chemical synthesis steps-> Controlled hierarchical synthesis
Additional iteration leads to a higher generation dendrimer
animation
Generation
Synthesis
Starts from multifunctional core.
A monomer unit with one reactive site and two protective sites is attached to a core molecule to iterate the first generation.
End points at surface are activated to continue to iterate the next generation.
Divergent synthesis
Synthesis
Starts from end points and ends at core.
Branching architecture starts from external dendron surface, and process toward internal active dendron.
A subunit with at least two peripheral branches reacts with an active site of an another subunit.
Finally, the subunit is attached to a core molecule to produce symmetrical dendrimer.
Convergent synthesis
Characteristics
Compact nm-scale dendrimer structure results in high solubility and low solution viscosity.
Dendrimers can provide both isotropic and anisotropic assemblies.

참고 자료

http://www.sigmaaldrich.com/Area_of_Interest/Chemistry/Materials_Science/Nanomaterials/Dendrons.html
http://dnanotech.com/dendrimerOverview.pdf
http://www.dendrimercenter.org/