Quinolinedione 유도체에 의한 혈관 수축작용 및 급성독성 연구
(주)코리아스칼라
- 최초 등록일
- 2023.04.05
- 최종 저작일
- 1999.09
- 5페이지/ 어도비 PDF
- 가격 4,000원
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 한국식품위생안전성학회
ㆍ수록지정보 : 한국식품위생안전성학회지 / 14권 / 3호
ㆍ저자명 : 정진호, 이주영, 유충규, 이선구, 배옥남, 김화정, 강규태
영어 초록
Effect of quinolinedione derivative (OQ-21) on phenylephrine induced vasoconstriction was investigated using aortic rings in organ bath isolated from rats. Treatment with OQ-21 resulted in moderate increase in vasoconstriction in a dose-dependent manner. In addition we studied acute intraperitoneal toxicity of OQ-21 in male and female ICR mice. The changes of body weight and clinical signs were observed for 7 days after single dose of OQ-21 from 50 mg/kg to 500 mg/kg. There were no significant changes in body weight and clinical signs. Any mouse didn't die even at maximal dose. Autopsy of OQ-21 treated mice revealed no abnormal difference from contol mice, These results suggest that OQ-21 be moderately safe and could be developed as effective drug.
참고 자료
없음
"한국식품위생안전성학회지"의 다른 논문
더보기 (5/10)