결명자추출물과 노르 - 루브로푸사린의 산화적 스트레스억제효과 및 항염색체손상 효과
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- 2023.04.05
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서지정보
ㆍ발행기관 : 한국식품위생안전성학회
ㆍ수록지정보 : 한국식품위생안전성학회지 / 13권 / 4호
ㆍ저자명 : 김수희, 최재수, 허문영
영어 초록
The antioxidative, radical scavenging and cyto-protective effects of Cassia torn L. seeds and it major component, nor-rubrofusarin-6-β-D-glucoside (nor-rubrofusarin), were studied to evaluate their inhibitory activity against hydrogen peroxide-induced oxidative stress. 70% ethanol extract of Cassia tora L. seeds and nor-rubrofusarin also were tested for the evaluation of anticlastogenicity against mitomycin C-induced micronucleated reticulocytes in mouse peripheral blood. The extract of Cassia tora seeds and nor-rubrofusarin showed an antioxidative effect on the lipid peroxidation of ethyl linoleate with Fenton's reagent and free radical scavenging effect to DPPH radical generation, respectively. They showed a protective effect against H₂O₂-induced cytotoxicity in CHL cells. The extract of Cassia tora L. seeds and nor-rubrofusarin showed a strong anticlastogenicity against mitomycin C-induced micronuclei formation. Results from our study indicate that the extract of Cassia tora L. seeds and nor-rubrofusarin are capable of protecting the lipid peroxidation, free radical generation and cytotoxicity induced by reactive oxygen species. They also have an anticlastogenicity toward DNA crosslinking agent like mitomycin C.
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