DRUG FEVER

소개글

DRUG FEVER에 대한 논문요약.

목차

1.Introduction
2. Mechanism
3 Clinical feature
4 Diagnosis and Treatment

본문내용

1. Introduction
-drug feve는 cutaneous manifestation 없이 febrile response가 일어나는 것을 말함.
-입원 환자의 약 10%에서 발생

2. Mechanism : 명확하게 알려지지는 않지만 대략 5개의 카테고리로 나뉨.

(1) altered thermoregulatory mechanisms
① increases the metabolic rate and thereby increases heat production : exogenous thyroid hormone
② vasoconstriction(decreased heat dissipation) : sympathomimetic agents (epinephrine, cocaine, amphetamine)
③ anticholinergic activity(impairment of the sweating mechanism) : atropine, antihistamines, tricyclic antidepressants, phenothiazines, and butyrophenone tranquilizers
④ elevating levels of tissue catecholamines : Monoamine oxidase inhibitor
⑤ blocks H2 receptors in the hypothalamus : Cimetidine

참고 자료

Drug fever : Diane H. Johnson MD Burke A. Cunha MD
From the Infectious Disease Division, Winthrop-University Hospital, Mineola, NY; and the State University of New York School of Medicine, Stony Brook, NY