X-ray crystallography 이론 및 응용

목차

1. Background and rationale
2 Methods of high throughput protein crystallography
3. Principle

본문내용

▶For Much higher criteria for drug design purposes
▶For understanding of the structural basis for molecular function, not just for one enzyme, but for whole functional pathways

Fragment-based approach to lead discovery. (a) Schematic representation of an active site with three sub-sites or pockets; (b) fragments binding in two of the pockets; (c) three fragments in pockets linked by a scaffold; (d) strategy for ‘growing’ a fragment in one pocket into the other pockets; (e) a real binding site defined by the van der Waals surface; (f) a fragment defined by X-ray crystallography in a pocket; and (g)a larger molecule obtained by growing the fragment shown in (f) into an adjacent pocket.

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