The p53 pathway
- 최초 등록일
- 2012.04.24
- 최종 저작일
- 2011.01
- 15페이지/ MS 파워포인트
- 가격 1,000원
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목차
The regulation of p53 function
choice of responses to p53
본문내용
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)
Mdm2 is an important negative regulator of the p53 tumor suppressor.
Mdm2 Overexpression : Ras와 cooperation
-> primary rodent fibroblast transformation
Nude mice에서의 Mdm2의 expression
-> tumor formation
The human homologue of this protein is sometimes called Hdm2.
human tumor types have been shown to have increased levels of Mdm2.
soft tissue sarcomas, osteosarcomas, breast tumors
Mdm4 (also called MdmX) is also an important negative regulator of p53.
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