allergy

소개글

contact dermatitis에 관한 매우 자세한 PPT 입니다. 기전에 관한 설명이 주된 내용입니다.

목차

Delayed-type hypersensitivity

Allergic Contact Dermatitis

Allergic Contact Dermatitis

Sensitization Phase

First Step

Second Step

Third Step

Elicitation Phase

Fourth phase

Fifth phase

Sixth phase

본문내용

First Step : Antigen Invasion and Activation of LCs
Second Step : Migration of LC to the Regional LN
Third Step : Antigen presentation to Naive T cells at the LN
Sensitization Phase

Allergens bind directly to MHC class II molecules inducing a sensitization reaction.
MHC class II molecules are coded on the human leukocyte antigen(HLA)-D region genes , and are present on epidermal DCs and LCs.
Epicutaneously applied allergen associates with APCs within 6 hours.
First Step

Epidermal LC take antigens(haptens) up and become activated with the augmentation of expression of various-costimulatroy molecules , such as CD54, CD80, and CD86, and the increased production of proinflammatory cytokines such as IL-1ß, TNF- α, and IL-12.
→ activation, maturation, and migration of LC
→ in the absence of co-factors, tolerance would develop
First Step

참고 자료

http://www.truetest.ca/Patient/Patindex.htm