SAg
- 최초 등록일
- 2012.01.16
- 최종 저작일
- 2012.01
- 32페이지/ MS 파워포인트
- 가격 900원
소개글
superantigen에 관한 매우 자세한 내용을 담은 PPT 입니다. 최신 저널 및 교과서를 참고하였습니다.
목차
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본문내용
SAg mediated activation of T-cell
SAg are not processed and they are not antigens in the traditional sense
They bind directly to the Vβ chain of the TCR and to the MHC molecule outside the antigen binding groove
This triggers clonal expansion of T-cells and an unregulated outpouring of pro-inflammatory cytokines.
Non-specific T cell activiation
Massive T-cell activation
Uncordinated, nonspecific release of proinflammatory cytokines
Recruit other T and B cells
Coactive APCs
⇒ some degree of immunosuppression
SAg mediated activation of T-cell
Vβ chains : homology 80%
Each SAg : specific Vβ “signature”
Toxic shock syndrome toxin-1(TSST-1)
: Vβ 2 isotype
Staphylococcal enterotoxin B(SEB)
: Vβ 3,12,14,15,17, and 20 isotype
diagnostic tool
determined by genetic makeup
참고 자료
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