Multiple sclerosis

소개글

Multiple sclerosis에 관한 정리글입니다.

목차

Multiple sclerosis
Dermographics and epidemiology
Etiology
Pathology, Pathogenesis & Pathophysiology
Type
Variant
Diagnosis
Impairment and Disability ratings
Medical management

본문내용

Multiple sclerosis
Medication-> reducing relapses or slowing down progression, Not improve the patient
The only way to improve fuction in MS is rehabilitation

Dermographics and epidemiology
85% relapsing-remittinet(R-R) or secondary progressive(SP) disease ; 2.5:1 female
10%-15% primary progressive foam(PP) 1:1, older

Etiology
Considered Autoimmune disease
women > men, Genetic & latitudinal difference-Northern European families
Aberration in Ab-Ag systems

Pathology, Pathogenesis & Pathophysiology
The hallmark of the pathological findings in MS- multifocal plaques of demyelination in the cerebral hemisphere, optic nerves, brain stem, and spinal cord
1) BBB
TJ abnormalities->Blood-Brain barrier disruption-> entry of active immune cells& serum protein into CNS, entry of neurolelectric blocking factors into active plaques near neuron -> Extracellular matrix alteration
;BBB in target of currently used disease modifying agents.

참고 자료

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