Increase of Liver Organ Weight in B6C3F1 Mice Fed with High dose Stevioside for 14 Days

서지정보

ㆍ발행기관 : 한국식품위생안전성학회 ㆍ수록지정보 : 한국식품위생안전성학회지 / 27권 / 3호
ㆍ저자명 : Hye-young Lee, Jong-Koo Kang, In-Seok Bang, Cheol-Beom Park

목차

ABSTRACT
Introduction
Materials and Methods
Test compound
Test Animals
Doses and administration of the stevioside
Clinical signs and mortality
Necropsy
Organ weight
Histopathology
Statistical analysis
Results
Analyses of test diet formulation.
Clinical sign and Mortality
Body weight, Food consumption and steviosideintake
Necropsy findings
Organ weight
Histopathological findings
Discussion
Acknowledgment
References

영어 초록

Stevioside, a natural sweeteners presently used in various kinds of food and food products in Korea, was evaluated for its toxicity potential in the 14 day feeding study using B6C3F1 mice. Stevioside was added to the diet at different concentrations of 0.31, 0.62, 1.25, 2.5 and 5%, and was administered for 14 consecutive days. An increase of liver organ weight in male mice was observed. No diet-related differences were noted in clinical signs, food consumption, and gross and histopatholgical evaluation. Based on these results, we concluded that the concentration of 5% in the diet was a suitable maximum tolerable dose of stevioside for a 90 day study in mice.

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