엉겅퀴에서 분리 정제한 Silymarin 의 사람 Low Density Lipoprotein 에 대한 항산화 효과
(주)코리아스칼라
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- 2023.04.05
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서지정보
ㆍ발행기관 : 한국식품위생안전성학회
ㆍ수록지정보 : 한국식품위생안전성학회지 / 12권 / 1호
ㆍ저자명 : 이백천, 진성현, 조경자, 김동석, 류병호
영어 초록
This study was pcrformed to evaluate the antioxidant activity of silymarin against human low density lipoproteins(LDL) oxidation. Silymarin extracted from Silybum marianum was successively purified with solvent fractionation and followed by silica gel column chromatography. The active substances were separated by HPLC and the isolated active substances, silymarin were identified by IR, NMR, GC-MS as silymarin. Silymarin inhibited at the 5 uM Cu^(2+)-mediated oxidation of human low density lipoprotein (LDL) in a dose dependent manner. Silymarin completely inhibited LDL oxidation at 50 ug/ml concentration. These findings suggest that silymarin may protect LDL against oxidation in atherosclerotic lessions.
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