[의학약학]Aging of Skin (피부의 노화)

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Aging of Skin (피부 노화에 관한 의학적인 정리)내용입니다.

목차

THEORIES OF AGING
The Programmatic Theory
TELOMERE SHORTENING
CELLULAR SENESCENCE
The Stochastic Theory
OXIDATIVE STRESS AND THE RATE OF LIVING
AMINO ACID RACEMIZATION
NONENZYMATIC GLYCOSYLATION
AGING AND THE IMMUNE SYSTEM
SKIN AGING
Clinical and Histologic Skin Changes

본문내용

THEORIES OF AGING
two basic theories of aging
1) programmatic theory states
: aging, like development, is a preordained process due to an inherent genetic program
2) stochastic theory states
: cumulative environmental damage to genes and proteins, homeostatic failure.
The Programmatic Theory
TELOMERE SHORTENING
- Telomeres : many hundreds of tandem short sequence repeats (TTAGGG)
mitosis 동안에 각각의 chromosome의 final base pairs가 replicate 되지 않음. 따라서 cell division이 지속되면 telomere가 짧아짐.
- short telomeres로 인해 cell cycle arrest 와 apoptosis가 일어남.
)

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