Apoptosis

소개글

Apotosis에 대한 이론뿐 아니라 실험에 대한 전반적인 내용 ppt 입니다.

목차

Relevance of apoptosis in health and disease
Two different types of cell death
Key elements of the apoptotic pathway include:
Apoptotic Parameters
Apoptotic Parameters
Two Different Types of Cell Death
Apoptotic Parameters
DNA Fragmentation
Apoptotic Parameters
Assays that measure membrane alterations
Fluorescent nucleic acid labeling dyes
Cell membrane alterations
Detection of apoptosis-related proteins
Fas signaling pathway

본문내용

* Relevance of apoptosis in health and disease
Apoptosis is a systematic and genetically programmed process.

Apoptosis is involved in tissue homeostasis and cell differentiation.

Apoptosis is directly involved in degenerative diseases (e.g. Alzheimer, Parkinson), autoimmune disorders (e.g. Rheumatoide arthritis), viral diseases(e.g.AIDS), and neoplasia (cancer development).

*Key elements of the apoptotic pathway include:
Death receptors
Apoptosis has been found to be induced via the stimulation of several different cell surface receptors in association with caspase activation.

Membrane alterations
In the early stages of apoptosis, changes occur at the cell surface and plasma membrane. One of these plasma membrane alterations is the translocation of phosphatidylserine (PS) from the inner side of the plasma membrane to the outer layer, by which PS becomes exposed at the external surface of the cell.

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