Dextrin과 β-cyclodextrin이 생체 내에서 헛개나무 추출물의 알코올성 손상으로부터 간보호에 미치는 영향

서지정보

ㆍ발행기관 : 한국식품위생안전성학회 ㆍ수록지정보 : 한국식품위생안전성학회지 / 30권 / 1호
ㆍ저자명 : 홍철이, 김진범, 노혜지, 나천수

목차

재료 및 방법
실험동물의 사육 및 군의 분류
헛개나무과병 추출분말 제조 및 경구 투여
지표성분 안정성 분석
식이 및 체중측정
혈액채취 및 조직적출
혈액생화학적 검사
Alcohol dehydrogenase 및 aldehyde dehydrogenase활성도 측정
통계분석
결과 및 고찰
헛개나무 지표성분의 안정성
체중 및 장기무게 변화
혈액 생화학적 지표분석
혈중 alcohol dehydrogenase 및 aldehyde dehydrogenase활성도 측정
결 론
References

영어 초록

β-cyclodextrin has an ability to protect compounds from oxidative reaction by collecting them within its ring-like structure. So, In harsh condition (40oC), marker compound, quercetin, was dramatically reduced in Hovenia dulcis fruit extract containing dextrin at 4 and 8 week compared to 0 week, but not that containing β-cyclodextrin. To evaluate the effects of dextrin and β-cyclodextrin on protective effect of H.dulcis fruit extract against alcohol- induced liver damage, The mice were orally injected alcohol, H. dulcis fruit extract/dextrin (HD) and H. dulcis fruit extract/β-cyclodextrin (HCD), respectively, for 7 days. The mice orally administrated with alcohol significantly enhanced the serum concentration of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the activity of lactate dehydrogenase (LDH) in serum compared to the control group. HD and HCD significantly decreased the levels of serum ALT and AST and serum LDH activities compared to alcohol group. And also alcohol group significantly increased the level of total cholesterol compared to the control group, but HD and HCD significantly reduced it compared to the alcohol group. However, the levels of TG in blood were not significantly changed in all groups. The activities of alcohol dehydrogenase (ADH) were significantly increased in HD and HCD group although those of aldehyde dehydrogenase showed an increasing tendency. This data suggested that HD and HCD were able to induce alcohol degradation in the liver tissues. All together, the results showed that HCD demonstrated their ability to protect liver from alcohol-induced damage on equal terms with HD.

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