The SARS-CoV-2 Delta variant spike protein facilitates cell–cell fusion
(주)코리아스칼라
- 최초 등록일
- 2023.04.03
- 최종 저작일
- 2022.09
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서지정보
ㆍ발행기관 : 한국예방수의학회(구 한국수의공중보건학회)
ㆍ수록지정보 : 예방수의학회지 / 46권 / 3호
ㆍ저자명 : Jinman Kim, Seokin Kim, Jung-Eun Park
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
Cells
Plasmids
Cell-cell fusion assay
Western blot
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
영어 초록
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates virus entry by binding to the host cell receptor, human angiotensin converting enzyme 2 (hACE2), and catalyzing virus–host membrane fusion. The S protein also mediates cell–cell fusion, potentially allowing the virus to spread virion-independently. Here, we compared the fusogenicity of SARS-CoV-2 variant S proteins using a cell–cell fusion assay. In cells overexpressing hACE2, cell–cell fusion ability of all tested SARS-CoV-2 variants was similar to that of the Wuhan-Hu-1 strain. However, in cells with endogenous hACE2, SARS-CoV-2 variants, especially the Delta variant, stimulated significantly greater cell–cell fusion than the original strain. Our results showed that the Delta variant S protein is highly fusogenic and can spread rapidly by utilizing small amounts of hACE2.
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