Anti-oxidant and Anti-inflammatory Effects of Rutin and Its Metabolites
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- 2016.04.01
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- 2013.09
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서지정보
ㆍ발행기관 : 경북대학교 농업생명과학대학
ㆍ수록지정보 : Current Research on Agriculture and Life Sciences / 31권 / 3호
ㆍ저자명 : Ji Hye Kim, Sang Hee Park, Eun Ji Beak, Chang Hee Han, Nam Joo Kang
영어 초록
Rutin is one of the major flavonoids found in buckwheat (Fagopyrum esculentum Moench). While rutin is already known to exhibit anti-oxidative, anti-inflammatory, and anti-carcinogenic activities. However, the health beneficial function of rutin metabolites is not well understood. In DPPH radical scavenging assays, the present study found that 3,4-dihydroxyphenyl acetic acid had the highest total anti-oxidant activity, followed by 3,4-dihydroxyphenylacetic acid, rutin, homovanillic acid, and 3-hydroxyphenyl acetic acid. Further, 3,4-dihydroxyphenylacetic acid strongly reduced LPS-induced IL-6 production in RAW 264.7 cells, compared with other metabolites. Therefore, these results suggest that rutin metabolites have potential to be utilized as food ingredients with anti-oxidant and anti-inflammatory activities.
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