EstrogenicXenobiotics가 돼지 정자의 운동성 및 운동역학에 미치는 영향
(주)코리아스칼라
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- 2016.04.01
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- 2011.03
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서지정보
ㆍ발행기관 : 한국동물번식학회
ㆍ수록지정보 : Reproductive & developmental biology / 35권 / 1호
ㆍ저자명 : 오신애, 박유진, 송원희, El-Sayed A. Mohamed, 방명걸
목차
ABSTRACT 서론 재료 및 방법 배양액 및 시약조성 정액처리 정자 운동성 및 운동역학 검사 통계분석 결과 고찰 인용문헌
영어 초록
Endocrine disruptors bind to hormone receptors on sperm membrane, therefore spermatozoa are potentially a useful model for examining estrogenic activities of endocrine disruptors. The objective of this study was to compare the effects of two xenoestrogenic compounds [genistein (Gen) and 4-tert-octylphenol (OP)] to those of two steroids [estrogen (E2) and progesterone (P4)] on boar sperm % motility and motion kinematics of in vitro. Porcine spermatozoa were incubated with various concentrations (0.001~100 μM) of each chemical for 15 or 30 min, and then assessed % motility and sperm motion kinematics using computer assisted sperm analyzer (CASA). Each chemical decreased sperm % motility, and OP decreased VSL and VAP compared with untreated control(p<0.05). E2 stimulated the motion kinematic changes except VCL. Moreover, Gen had effects on VCL and VAP alterations after 30 min incubation. In summary, since all chemicals studied effectively altered sperm % motility and motion kinematics, it was concluded that porcine spermatozoa could be a useful model for in vitro screening of potential endocrine disruptors.
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