New artificial nerve conduits made with photocrosslinked hyaluronic acid for peripheral nerve regeneration

소개글

hyaluronic acid를 이용하여 하이드로젤을 제작하여 신경의 재생을 위한 관(conduit)을 제작하여 in vitro상에서 관의 내부에 신경 세포를 배양하므로써 나타나는 세포의 증식변화를 살펴 보고자함

목차

Introduction
Materials and methods
Results
Discussion

본문내용

For peripheral nerve regeneration, three-dimensional distribution and growth of cells within the porous scaffold are
of clinical significance. We demonstrate that cultured rat Schwann cells and neurospheres grow in vitro on new artificial nerve
conduits made with photocrosslinked hyaluronic acid (HA). HA tubular conduits have an inner diameter of 1.2 mm with porous
nano-structure of 50 μm. After 3 weeks of cultivation, HA conduits remained circular with a round lumen, and construct of
cell-conduits maintained the size and shape of the original architecture of the tube. HA itself has the function to facilitate a
pathway for cellular and axonal ingrowth during peripheral nerve regeneration. These findings provide the feasibility of using
the HA conduits for better cell adhesion and differentiation, leading to axonal regeneration in peripheral nerve reconstruction.

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